Grant OPUS-22 + LAP NCN for the Nencki Institute

The consortium led by Prof. Mariusz Wieckowski has been granted with
OPUS-22 + LAP NCN funding, carried out in international collaboration under the
WEAVE Programme for the project: „The role of impaired autophagy and
peroxisome function in NAFLD development and their targeted recovery for
improved efficacy of n-3 fatty acids”.
The consortium consists of Nencki Institute, Warsaw Medical University
and Institute of Physiology of the Czech Academy of Sciences.

The main goal of the project is unraveling the role of autophagy in non-
alcoholic fatty liver disease (NAFLD) progression and to develop potential novel
strategies to delay disease progression. Additionally, we aim to determine
whether treatment with inducers of autophagy can increase the effectiveness of
supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) towards the
advanced stages of NAFLD, which is otherwise limited to the initial step in
NAFLD (i.e, hepatic steatosis).


20 July 2022