I would like to invite you for a lecture on 1st of July at 3pm of dr Witold Konopka from the Laboratory of Neuroplasticity and Metabolism, Department of Life Sciences and Biotechnology Lukasiewicz PORT - Polish Center for Technology Development.
He will present his lecture entitled: "Proteins regulating RNA function in neuronal plasticity"
His habilitation is processed by the Scientific Council of the Nencki Institute of Experimental Biology.
The proper functioning of the central nervous system is based on cellular homeostasis. The loss of homeostasis leads to excessive or insufficient activation of neuronal network, which consequences can be observed in a broad spectrum of neurological diseases. The chronic disturbances of neuronal network activation are also associated with neurodegenerative disorders. There is a theory of plasticity-pathology continuum indicating that our ability to acquire and store new information is based on the same molecular mechanisms as processes observed in degenerating neurons. The only difference is the strength of stimulation and time of action which may be beneficial or deleterious for human brain. For the above reason, studying a memory formation mechanisms may, in addition to acquiring basic knowledge, indicate directions for the development of future therapies for neurological disorders. Precise control of neuronal activity in circuits involved in a variety of physiological functions seems to be the most important aspect of development of targeted interventions such as genetic modifications of selected cell types. The results of studies on the proteins that regulate a function of RNA processing, namely the Dicer – a key ribonuclease in microRNA processing and the TDP-43 – a nuclear protein that belongs to the heterogeneous ribonucleoproteins family and is involved in the regulation of gene transcription and RNA processing will be presented. Both proteins are of special interest in the context of neuronal plasticity. Transgenic animals – rats and mice and animals modified by other methods of genetic manipulation i.e. oligonucleotide technology were used as research models.
Link to the meeting:
Meeting ID: 916 8828 0486