I would like to cordially invite you to the next Nencki Institute Seminar which will take place on the 10th of February at 3pm. We will host Prof. Martin Klingenspor, Chair of Molecular Nutritional Medicine at the Technical University of Munich within the School of Life Sciences Weihenstephan. Prof. Klingenspor will give a lecture entitled: More than a furnace: Thermogenic adipocytes listen to the gut and talk to the brain.
Two different types of adipose tissues with contrary functions play an essential role in energy balance regulation. While white adipose tissue stores excess calories in the form of energy-rich triglycerides, brown adipose tissue is used for thermogenesis in the defence of cold. The heating mechanism in brown adipocytes, known as nonshivering thermogenesis, wastes chemical energy by uncoupling mitochondrial oxygen consumption from ATP synthesis. This unique biochemical mechanism for thermogenesis depends on uncoupling protein 1 (UCP1), expressed exclusively in thermogenic brown and brite adipocytes. The latter represent inducible brown (or beige) adipocytes in white adipose tissue. The discovery of functional brown fat in healthy adults has spurred the search for pharmacological and nutritional interventions to recruit and activate this heating organ for the treatment of metabolic disorders. All the more so because thermogenic brown and brite adipocytes are not only activated in response to cold but also induced while eating. Our research addresses the impact of thermogenic adipocytes on diet-induced obesity and aims to elucidate the underlying physiological mechanisms.
Recent review on this topic: doi:10.1210/endocr/bqab113
The meeting will be online only. Here is the link:
Meeting ID: 982 2223 1110